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Fragile X fixed in mice – Nature

Posted by on May 18, 2012 in Archived Articles | 0 comments

A molecule that inhibits a neurotransmitter receptor reverses many of the symptoms in a mouse model of fragile X syndrome, the most common form of inherited mental retardation. The disorder is caused by mutations in the FMR1 gene that result in overactivity of the mGlu5 receptor. For more information, visit: http://www.nature.com/nature/journal/v484/n7394/full/484291d.html

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Fragile X Syndrome May be Reversible – The Jackson Laboratory

Posted by on May 18, 2012 in Archived Articles | 0 comments

Is fragile X syndrome (FXS) reversible – even if treated after the brain is fully developed? A research team led by Drs. Lothar Lindemann of F. Hoffmann-La Roche, Switzerland, and Mark Bear of the Massachusetts Institute of Technology, Cambridge, MA, suggests that it is. The research team found that a novel compound reverses FXS in mouse models of the disease – even if administration starts when the mice are four to five weeks old and all FXS-related phenotypes are established. For the full story, visit:...

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Research Summit on Emerging Causes of Fragile X and Autism

Posted by on May 18, 2012 in Archived Articles | 0 comments

The Gordon Research Conference, “Fragile X and Autism-Related Disorders: From Basic Neuroscience to Improved Clinical Care,” will be held June 10 through 15, at Stonehill College, in Easton, Mass. Chaired by Elizabeth Berry-Kravis, M.D., Ph.D., and co-chaired by Jennifer Darnell, Ph.D., the upcoming conference on fragile X and autism was initiated because of recent dramatic progress in understanding the overlapping genetic and biological pathways in these and related neurodevelopmental disorders. Read more at:...

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JS Genetics Announce Launch of its Bloodless, Cheek Swab Test for Fragile X Syndrome

Posted by on May 18, 2012 in Archived Articles | 0 comments

JS Genetics announces the launch of XCAT-FX, its propitiatory buccal swab test for the detection of Fragile X syndrome. Fragile X syndrome is the most common cause of inherited intellectual disability (mental retardation) in males and a leading cause of infertility and fragile X-associated primary ovarian insufficiency in females. Fragile X is also the most common known genetic (single gene) cause of autism. This PCR based test can identify Fragile X in both males and female patients. Read the full store at:...

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